Effectiveness of mouthwash in preventing traumatic ulcers in orthodontic patients : 
Orthodontic treatment can cause traumatic ulcers within the first month due to friction and irritation. Curcumin, a turmeric extract, exhibits analgesic, anti-inflammatory, antibacterial, and wound-healing properties. This study investigated the effectiveness of  mouthwash in preventing traumatic ulcers in fixed orthodontic patients during the first month of treatment.
Methods: 
In this double-blind, placebo-controlled, randomized clinical trial, 70 patients aged 12–30 years were assigned to mouthwash or placebo  used twice daily for 28 days after bracket cementation. Primary outcomes were (1) incidence and (2) duration of traumatic ulcers. Secondary outcomes included pain scores, ulcer sites, adverse effects, plaque index (PI), gingival index (GI), gingival bleeding index (GBI), and patient feedback. 
All 70 patients completed the trial, with 35 participants in the mouthwash group (mean age 20.88 ± 4.87 years) and 35 in the placebo group (mean age 18.60 ± 4.20 years). No significant between-group differences were observed in the incidence or duration of traumatic ulcers (p > 0.05). Patients in the mouthwash group reported significantly lower pain scores compared with those in the placebo group during the first and second weeks (p < 0.05), indicating an early analgesic effect; however, no significant differences were observed thereafter.
Conclusions :
Although ulcer prevention was not observed, mouthwash may serve as an adjunct for early pain relief in orthodontic patients.